CD11c expression in B-cell chronic lymphocytic leukemia [letter]

CD11c expression in B-cell chronic lymphocytic leukemia.

Sir, CD79b monoclonal antibody (B29) identifies a Bcell restricted molecule that is part of the mb1/B29 disulphide-linked heterodimer which is non-covalently associated with membrane IgM and IgG to constitute the B-cell antigen receptor complex.1 Both B29 and mb1 are restricted to B-lymphocytes, first appearing on the surface at the pre-B-cell stage and remaining through all stages of B-cell di...

B-cell Chronic Lymphocytic Leukemia

Purpose: To review the recent major advances in the molecular and cell biology of B-cell chronic lymphocytic leukemia (B-CLL). Methods: Weanalyzed thenatureofmalignantB-CLLB cells and their interactions with the microenvironment. Results: B-CLL is a malignancy of a mantle zonebased subpopulation of anergic, self-reactive, activated CD51 B cells devoted to the production of polyreactive natural ...

Analysis of HLA-G Gene Expression in B-Lymphocytes from Chronic Lymphocytic Leukemia Patients

The human leukocyte antigen G (HLA-G) molecule exhibits limited tissue distribution, low polymorphism and alternative splicings that generate seven HLA-G isoforms. HLA-G exerts multiple immunoregulatory functions. Recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from anti-tumor immune responses. This study it is an effort to clarify the presence of HLA...

CD5+, CD11C+, trap-positive chronic lymphocytic leukemia/prolymphocytic leukemia.

CD11c expression in B-cell chronic lymphocytic leukemia. A comparison of results obtained with different monoclonal antibodies.

In order to obtain more information on the pattern of CD11c-positivity in otherwise typical B-cell chronic lymphocytic leukemia (CLL), we analyzed immunological and clinico-pathological features of 99 such patients studied with two different monoclonal antibodies (MoAbs). Fifty-two out of 70 (74.2%) patients stained with IOM-11C MoAb and 3 out of 29 (10.3%) patients stained with Leu-M5 MoAb had...